Monday, December 31, 2012

NEW STUDY: Renal fluoride excretion in children following topical application of

Department of Odontology,  Faculty of Biomedical Sciences, European
University of Madrid,  Spain.


To demonstrate that the  application of dental fluoride varnishes in
children increases urinary fluoride  excretion.


From a randomly assembled  group of 42 children aged between 5 and 8 years,
residing in a community with  non-fluoridated water, spot urinary samples
were taken before the topical  application of dental fluoride varnish and 2
hours afterwards. In an age-matched  control group of 16 children from the
same community, who received no treatment,  samples were taken the same way.
The urinary excretion of fluoride was analysed  by determining fluoride ion
(F-) level and fluoride/creatinine (F/Cr) ratio in  the urine.


In the study group, the  average pre- and post-treatment F/Cr ratios were
0.42 and 1.38 mg/g,  respectively (p < .001). No significant changes were
observed in the control  group, which received no treatment. The average 2
hours afterward F/Cr ratios  were 0.29 and 0.27 respectively (p = 0.426).


The topical application of  dental fluoride varnish leads to a significant
increase in urine F-, which is  attributable to the application of the


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